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Research papers regulation cell cycle

The length of the cell cycle is highly variable, even within the cells of a single organism. In humans, the frequency of cell turnover ranges from a few hours in early embryonic development, to an average of two to five days for epithelial cells, and to an entire human lifetime spent in G 0 by specialized cells, such as cortical neurons or cardiac muscle cells. There is also variation in the time that a cell spends in each phase of the cell cycle. When fast-dividing mammalian cells are grown in culture outside the body under optimal growing conditions , the length of the cycle is about 24 hours.

Cell Cycle regulation

Cell Cycle regulation Research Papers - zo-ook.info

The eukaryotic cells undergoes a series of coordinated events to ensure faithful replication of their genome. A disruption of these events may lead to cell death or oncogenic transformation. Hence, the processes of cell cycle are carefully regulated. Elucidating the role of effector proteins in cell cycle progression. A key step in the eukaryotic cell cycle is the G1 to S phase transition and this step is tightly coupled to the transcriptional control of genes involved in growth and DNA replication.

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Cell cycle is required by both unicellular and multicellular organisms to transmit their genetic information. It is well known that the major regulatory mechanism of eukaryotic cell cycle is determined by cyclin-dependent kinases CDKs and their cyclin partners. On the other hand, an increasing number of studies have shown that the regulation of cell cycle is quite subtle involving many factors. Research papers in this issue provide new insights into the regulation of cell cycle. Mitosis is an energy-cost process, in which homologous chromosomes have to be segregated and moved into two daughter cells.
But now University of Groningen scientists have found evidence that a metabolic oscillator acts as the "conductor" of cell division. Their results were published online in the journal Molecular Cell on December Cells go through repetitive cycles of DNA duplication, growth, and cell division.

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